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Author : Nate F. Cardarelli
Publisher : CRC PressI Llc
Page : 293 pages
File Size : 45,82 MB
Release : 1989
Category : Medical
ISBN : 9780849369094
v. 1. Thymus and immunity -- v. 2. Aging and endocrinology.
Author : Nathan F. Cardarelli
Publisher : CRC Press
Page : 352 pages
File Size : 13,40 MB
Release : 2019-07-17
Category : Medical
ISBN : 1000694658
First published in 1989: This text was written to provide a relatively broad comprehensive study of the thymus in health and disease, including relationships to the endocrine system, immue system, and again.
Author : Nate F. Cardarelli
Publisher : CRC PressI Llc
Page : 368 pages
File Size : 26,31 MB
Release : 1989
Category : Medical
ISBN : 9780849369100
v. 1. Thymus and immunity -- v. 2. Aging and endocrinology.
Author : Kazuwa Nakao
Publisher : Springer
Page : 330 pages
File Size : 35,34 MB
Release : 2015-10-13
Category : Science
ISBN : 4431556516
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Author : Marek P. Dabrowski
Publisher : CRC Press
Page : 378 pages
File Size : 45,95 MB
Release : 2019-06-04
Category : Medical
ISBN : 1000012557
First published in 1990. This important new text covers a wide area of thymology in both the theoretical and practical aspects. In view of current information, a crucial role of endocrine thymus is presented in the creation, maintenance, and senescence of neuro-endocrine-immune homeostasis. In particular, mechanisms are described (which are basically responsible for the T cell maturation and selection) for the hierarchic organization of the immune system and its thymic dependent immune competence in terms of tolerance and immunity. A detailed presentation of the structure and biological properties of a number of well-defined thymic hormones is included. Their clinical applications and results obtained in inherited or acquired immunodeficiencies and in neoplasmic diseases are also reviewed on the grounds of numerous representative clinical trials. A perspective and potential scope of immunorestorative therapy and prevention with thymic hormones and other thymomimetic drugs are outlined. Researchers, practitioners, and students will find this book to be a useful and essential source of information.
Author : Nathan F Cardarelli
Publisher : CRC Press
Page : 340 pages
File Size : 18,94 MB
Release : 2021-03
Category :
ISBN : 9780367262891
First published in 1989: This text was written to provide a relatively broad comprehensive study of the thymus in health and disease, including relationships to the endocrine system, immue system, and again.
Author : Nathan F. Cardarelli
Publisher : CRC-Press
Page : 0 pages
File Size : 34,89 MB
Release : 1989-07-31
Category : Medical
ISBN : 9780849369094
Author : Valquiria Bueno
Publisher : Frontiers Media SA
Page : 314 pages
File Size : 10,3 MB
Release : 2020-01-15
Category :
ISBN : 2889633616
The world population presents an increased percentage of individuals over 65 years old and the fastest growing subgroup is over 85 years old. The increase in life expectancy observed in the last century has not been synonymous with extra years lived in good health (disability-free years). Population studies have shown that as individuals age, they can present a great heterogeneity of ability and health. Therefore, aging has been associated for some individuals with disabilities and hospitalizations. Deaths related to infectious pathogens are increased in the aging population mainly due to pneumonia and influenza whereas Cytomegalovirus, Epstein-Barr virus, among other viruses seem to contribute to the low-grade inflammatory process observed (inflammaging). Aging is a complex and multifactorial process in which functions of the organism are adjusted (remodelled) in order to deal with damaging events during life. One of the most important changes in aging individuals occurs in the immune system (innate and adaptive responses) with consequences such as poor response to new infections and vaccinations; increased susceptibility to cancer development and autoimmune diseases; frailty, and organ dysfunction. In addition, it has been proposed that immunosenescence not only reflects the aging of the organism but also contributes to this process. Bone marrow presents decreased hematopoiesis, the thymus undergoes involution and lymphoid organs (lymph nodes, spleen) also present reduced functionality. Therefore, cells derived, matured, or residing in these tissues decline in number and function. These changes have been identified in experimental models, in vitro conditions, peripheral blood, and biopsies via biomarkers such as cell phenotype, stimulus-induced proliferation, cytokines and antibodies levels. Telomere length and telomerase activity also decline in bone marrow-derived and peripheral blood cells and have been shown to play a role in immunosenescence. More recently, the investigation of short non-coding RNA molecules (microRNAs; miRNAs) pointed to this system as a possible control of aging-related mechanisms. Data obtained on these markers for aging individuals could lead to the generation of a marker panel for pathology prediction, to indicate interventions, and to evaluate the efficacy of interventions. Interventions such as nutrition supplements, exercise, vaccination (different dose, concentration of antigen, adjuvants) have been proposed to circumvent age-related diseases. Considering the heterogeneity in the aging process, further investigation is vital before the indication of interventions for aging individuals. As the extension of life expectancy is a reality, it is a challenge to understand how the aging population copes with the remodelling of the organism and how interventions could provide longevity in good health.
Author : Mariastefania Antica
Publisher : Frontiers Media SA
Page : 129 pages
File Size : 49,61 MB
Release : 2022-09-23
Category : Medical
ISBN : 2832500544
Author : Tamas Fulop
Publisher : Springer Science & Business Media
Page : 1693 pages
File Size : 25,11 MB
Release : 2009-02-27
Category : Medical
ISBN : 1402090633
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.