[PDF] Mouse Models In The Study Of Genetic Neurological Disorders eBook

Author : Brian Popko
Publisher : Springer Science & Business Media
Page : 370 pages
File Size : 14,9 MB
Release : 2012-12-06
Category : Medical
ISBN : 146154887X

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The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a comprehensive compendium, but rather as an update of work in progress. It is exhilarating to witness the fast pace at which these models are being established as important tools in the study of basic neuroscience and neurological disorders. It will be even more exciting to see their utilization in the development and testing of therapeutic interventions for these diseases. I would like to thank each of the authors who have contributed to this volume for their time and their expertise. I would also like to thank Drs. Timothy Coetzee and Joshua Corbin for their advice in the selection of the topics covered. I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.

Author : Philippe Poindron
Publisher : Karger Medical and Scientific Publishers
Page : 109 pages
File Size : 22,87 MB
Release : 2008-01-01
Category : Medical
ISBN : 3805584059

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This publication describes in detail some animal models of outstanding importance for the study of human neurological diseases. An introductory article provides a definition of animal models, looks at the history and ethics of their use, and highlights the reasons why animal models are so useful in scientific research. The following chapters present some of the newer models which play a key role in the study of amyotrophic lateral sclerosis, multiple sclerosis, stroke and peripheral neuropathy. Their specific features are detailed in the method section of each paper, and their application to the study of human neurological diseases is discussed in a comprehensive manner, i.e. limits and challenges posed by these models are evaluated and potential improvements suggested. A valuable single source of information, this book is recommended reading for neuroscientists as well as for neurologists and neurosurgeons interested in preclinical research on human neurological diseases.

Author : Johan A. den Boer
Publisher :
Page : 496 pages
File Size : 19,87 MB
Release : 1995-07-11
Category : Medical
ISBN :

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Recent years have witnessed major advances in the study of neuroscience which have increased our understanding of the relationship between cerebral processes and behavioural, cognitive and emotional disorders. This series aims to monitor important research developments in the field of biological psychiatry and their relevance to clinical practice. Since the 1950s there has been significant progress in our understanding of the neurobiology of schizophrenia. This important volume illustrates these new developments, particularly in terms of pharmacotherapeutics, pathogenesis and research methodology. Eminent scientists from around the world discuss conceptual issues, epidemiology, genetic analysis of psychotic disturbances, neuropathological changes and brain imaging studies, atypical neuroleptics, psychopharmacology of schizophrenia, neuropeptide involvement, neurophysiology and information processing in schizophrenia. Also highlighted are the similarities between childhood developmental disorders and schizophrenia, as well as the relatively neglected area of biological factors in childhood psychosis and their predictive value in adult psychopathology. Psychiatrists, neuroscientists, pharmacologists, psychologists, physicians and general practitioners will find this authoritative state-of-the-art review important and informative reading.

Author : Edward D. Levin
Publisher : CRC Press
Page : 395 pages
File Size : 28,48 MB
Release : 2006-06-22
Category : Medical
ISBN : 1420004336

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The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Author :
Publisher : Academic Press
Page : 528 pages
File Size : 18,12 MB
Release : 2011-09-06
Category : Science
ISBN : 0080922481

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Approximately three percent of newborn humans have congenital anomalies with significant cosmetic and/or functional consequences. Much of our ability to understand what has gone awry in these birth defects rests with development of animal models for them; the mouse has emerged as the model organism of choice for these studies. This volume reviews mouse models of specific developmental genetic diseases, including neural tube defects; cleft lip and/or palate; congenital heart disease; ciliopathies; hereditary deafness and others to provide conceptual insight into congenital anomalies generally. The interplay between clinical observation and murine model systems is expected to yield deep insight into mammalian developmental processes and the emergence of effective preventive and/or therapeutic strategies. Provides busy clinical and basic science researchers a one-stop overview and synthesis of the latest research findings and contemporary thought in the area Allows researchers to compare and contrast disease models and also to learn about what models have been developed for large-scale distribution Allows researchers to evaluate basic differences in mouse and human biology and propose alternate pathways and possible gene interactions of the disease

Author : Charles Watson
Publisher : Academic Press
Page : 815 pages
File Size : 49,33 MB
Release : 2011-11-28
Category : Science
ISBN : 0123694973

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The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness

Author :
Publisher : Academic Press
Page : 284 pages
File Size : 31,2 MB
Release : 2022-04-20
Category : Science
ISBN : 0128171324

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Mouse Models of Development and Disease, Volume 148 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this volume presenting chapters describing Mouse models of Charcot-Marie-Tooth disease, Mouse models in palate and craniofacial development, Uterine morphogenesis, Improving the translatability of mouse models of Alzheimer's disease, Mouse models for the study of clustered protocadherins, Mechanisms of organ regeneration in the spiny mouse, Comparative studies of organ vascularization, Modeling human urinary tract development and hereditary malformations, Innervation in organogenesis, Between embryo and adult: somatic growth of the kidney, and Mouse models in the study of Notch signaling. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on Mouse Models of Development and Disease

Author : Anil Kumar
Publisher : Bentham Science Publishers
Page : 290 pages
File Size : 24,31 MB
Release : 2021-12-24
Category : Science
ISBN : 9815039695

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Animal disease models are a vital tool to study diseases and associated conditions. Studies on animal models can, in some cases, be used as a basis for modeling and understanding human diseases. Biomedical scientists face a challenge to choose the correct animal model to study disease pathology, and neurological diseases are no exception to this rule. Animal Models for Neurological Disorders covers different animal models which have been used for studying neurological disorders. 13 topical chapters have been contributed by a group of experts on the subject with an aim to cover emerging experimental models of a range of neurological diseases encountered in the clinic including Alzheimer’s disease, psychosis, Parkinson’s, Huntington’s disease, vascular dementia, schizophrenia, multiple sclerosis and brain tumors, among others. The chapters also inform readers about relevant clinical correlations in each disease model where appropriate. Animal Models for Neurological Disorders is intended for all scholarly researchers and students of biomedical sciences, pharmacology, medicine (oncology, neurology, psychiatry), pharmacy, biochemistry, and biotechnology. The organized contents of the book also serve as a quick reference point for scientists working in applied areas of neuroscience including the study of neurodegenerative diseases and cognitive dysfunction in living organisms.

Author : National Research Council
Publisher : National Academies Press
Page : 102 pages
File Size : 30,61 MB
Release : 2012-06-26
Category : Science
ISBN : 0309252113

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Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.