[PDF] Molecular Mechanisms Of Notch Signaling eBook

Author : Tilman Borggrefe
Publisher : Springer
Page : 417 pages
File Size : 10,9 MB
Release : 2018-07-20
Category : Science
ISBN : 3319895125

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This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.

Author : Jörg Reichrath
Publisher : Springer Nature
Page : 179 pages
File Size : 28,27 MB
Release : 2020-02-18
Category : Medical
ISBN : 3030364224

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This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.

Author : Melissa Helen Little
Publisher : Academic Press
Page : 615 pages
File Size : 32,32 MB
Release : 2015-08-06
Category : Science
ISBN : 012800438X

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Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Author :
Publisher :
Page : 25 pages
File Size : 27,45 MB
Release : 2002
Category :
ISBN :

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The purpose of this study is to identify the molecular mechanisms by which constitutive - expression of activated Notch alleles induces neoplasia. We hypothesize that neoplastic conversion of cells by Notch proteins proceeds through nuclear protein interactions within the previously identified minimal transformation domain. This work will identify protein partners Notch proteins utilize as effectors of neoplastic signal propagation. A major finding during the past year has been the identification and characterization of a high- molecular-weight Notch complex in the nucleus of cells transformed by Notch. This complex contains both CSL and Mastermind in addition to Notch and our data indicates that formation of this complex is likely required for neoplastic transformation by Notch. Current research is focused upon the function of Mastermind in both complex formation and activity in addition to characterization of complex formation by other Notch family members. Funding for this proposal over the past year has resulted in the publication of - one manuscript, and the presentation of one poster and one oral presentation at scientific meetings.

Author : Zoran Ivanovic
Publisher : Academic Press
Page : 328 pages
File Size : 29,68 MB
Release : 2015-11-28
Category : Science
ISBN : 0128006110

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Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration. Highlights the molecular and evolutionary features of stem cells which make them so important to all biological research Explores methods of isolation, characterization, activation, and maintenance of stem cells Includes models for clinical application in regenerative medicine, cancer therapy, and transplantation

Author : Toshio Nakanishi
Publisher : Springer Nature
Page : 374 pages
File Size : 11,59 MB
Release : 2020-02-28
Category : Medical
ISBN : 9811511853

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This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.