[PDF] Germline eBook

Author : T. C. McCarthy
Publisher : Orbit
Page : 213 pages
File Size : 33,40 MB
Release : 2011-08-01
Category : Fiction
ISBN : 0316179922

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Germline (n.) the genetic material contained in a cellular lineage which can be passed to the next generation. Also: secret military program to develop genetically engineered super-soldiers (slang). War is Oscar Wendell's ticket to greatness. A reporter for The Stars and Stripes, he has the only one way pass to the front lines of a brutal war over natural resources buried underneath the icy, mineral rich mountains of Kazakhstan. But war is nothing like he expected. Heavily armored soldiers battle genetically engineered troops hundreds of meters below the surface. The genetics-the germline soldiers-are the key to winning this war, but some inventions can't be un-done. Some technologies can't be put back in the box. Kaz will change everything, not least Oscar himself. Hooked on a dangerous cocktail of adrenaline and drugs, Oscar doesn't find the war, the war finds him.

Author : Nelson Erlick
Publisher : Macmillan
Page : 390 pages
File Size : 30,14 MB
Release : 2003
Category : Fiction
ISBN : 076530094X

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Scientist Dr. Kevin Kincaid finds himself at the center of a storm of controversy and murder when he announces he has developed a technique that would allow the introduction of new genes into the germ cells of babies while they are still in the womb, thus eradicating genetic diseases for future generations.

Author : The Royal Society
Publisher : National Academies Press
Page : 239 pages
File Size : 46,14 MB
Release : 2021-01-16
Category : Medical
ISBN : 0309671132

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Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Author : Steven X. Hou
Publisher : Humana Press
Page : 0 pages
File Size : 22,61 MB
Release : 2014-10-15
Category : Science
ISBN : 9781617378805

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In this comprehensive and cutting-edge book, leading experts explore the parameters that define germline stem cells and the mechanisms that regulate the cell behavior in order to better isolate, characterize and maintain them. The volume begins by providing protocols for germline stem cell identification and regulation in model organisms, and concludes with detailed chapters covering current techniques involving in vitro culture and the applications of the cells.

Author : Andrea Boggio
Publisher : Cambridge University Press
Page : 0 pages
File Size : 12,79 MB
Release : 2022-06-30
Category : Law
ISBN : 9781108718448

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The advent of the CRISPR/Cas9 class of genome editing tools is transforming not just science and medicine, but also law. When the genome of germline cells is modified, the modifications could be inherited, with far-reaching effects in time and scale. Legal systems are struggling with keeping up with the CRISPR revolution and both lawyers and scientists are often confused about existing regulations. This book contains an analysis of the national regulatory framework in eighteen selected countries. Written by national legal experts, it includes all major players in bioengineering, plus an analysis of the emerging international standards and a discussion of how international human rights standards should inform national and international regulatory frameworks. The authors propose a set of principles for the regulation of germline engineering, based on international human rights law, that can be the foundation for regulating heritable gene editing both at the level of countries as well as globally.

Author : Gregory Stock
Publisher : Oxford University Press
Page : 186 pages
File Size : 31,83 MB
Release : 2000-02-03
Category : Medical
ISBN : 0195350936

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This book explores the many prospects, challenges and ethical questions that surround the engineering of our reproductive cells. It is an accessible, three-part examination, moving from focused, realistic assessments of the promise and problems for this advancing technology to a section of short essays on the implications of our technological ability. Also included is a panel discussion in which leading scientists, ethicists, and public policy workers give voice to their thoughts and concerns regarding our impending genetic technologies. Many world leaders in these fields, including Leroy Hood, French Anderson, Mario Capecchi, Daniel Koshland, Michael Rose, Lee Silver, and James Watson, have contributed to this volume, providing the essential elements of the debate over germline engineering. If you have ever pondered the question: "Would I be willing to genetically alter my own child-to-be, given a safe, reliable technology, offering a tempting possibility?", this book will be an indispensable guide.

Author : Michael Buszczak
Publisher : Springer Nature
Page : 283 pages
File Size : 11,15 MB
Release : 2023-07-18
Category : Science
ISBN : 1071632590

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This third edition volume expands on the previous editions with new discussion on the latest techniques and model systems used to study germline stem cells. The chapters in this book cover topics such as analysis of the C. elegans germline stem cell pool; live imaging of the Drosophila testis stem cell niche; standardization of single-cell RNA-sequencing analysis workflow to study Drosophila ovary; 3D analysis of the intact mouse ovary; and derivation and primordial germ cell induction of intermediate pluripotent stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Germline Stem Cells: Methods and Protocols, Third Edition is a valuable resource for all researchers in the germ stem cell community interested in learning more about this developing field.

Author : Roland Dosch
Publisher :
Page : 383 pages
File Size : 35,37 MB
Release : 2021
Category : Cell differentiation
ISBN : 9781071609705

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This volume details a wide range of methods, ranging from beginner through advanced, used to further study zebrafish and fish germline. Chapter guide readers through cultivating and manipulating germ cells, imaging of germline processes and the molecular analysis of their, protein, and RNA. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Germline Development in the Zebrafish: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Author :
Publisher : Academic Press
Page : 365 pages
File Size : 23,43 MB
Release : 2019-05-31
Category : Science
ISBN : 0128097531

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The Immortal Germline, Volume 135 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Balbiani body, germ plasm and polarity, Wolbachia and the germline, Human germ line biology, Reproduction/immunity and sperm success, Mammalian spermatogenesis, Reproduction/regeneration and germ cells in planarians, Germline stem cell homeostasis, Germline soma interactions/sex determination, Reconstituting the mouse germ-cell specification pathway in vitro, Maternal Germ line inheritance of mitochondria, Transposon strategies, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Includes the latest information on germ cells

Author : Kate MacCord
Publisher : University of Chicago Press
Page : 172 pages
File Size : 34,5 MB
Release : 2024-01-05
Category :
ISBN : 0226830519

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A concise primer that complicates a convenient truth in biology--the divide between germ and somatic cells--with far-reaching ethical and public policy ramifications. Scientists have long held that we two have kinds of cells--germ and soma. Make a change to germ cells--say using genome editing--and that change will appear in the cells of future generations. Somatic cells are "safe" after such tampering; modify your skin cells, and your future children's skin cells will never know. And, while germ cells can give rise to new generations (including all of the somatic cells in a body), somatic cells can never become germ cells. How did scientists discover this relationship and distinction between somatic and germ cells--the so-called Weismann Barrier--and does it actually exist? Can somatic cells become germ cells in the way germ cells become somatic cells? That is, can germ cells regenerate from somatic cells even though conventional wisdom denies this possibility? Covering research from the late nineteenth century to the 2020s, historian and philosopher of science Kate MacCord explores how scientists came to understand and accept the dubious concept of the Weismann Barrier and what profound implications this convenient assumption has for research and policy, from genome editing to stem cell research, and much more.