[PDF] Bone Metastases From Prostate Cancer eBook

Author : Francesco Bertoldo
Publisher : Springer
Page : 293 pages
File Size : 37,92 MB
Release : 2016-11-07
Category : Medical
ISBN : 3319423274

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This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.

Author : James P. Karr
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 46,2 MB
Release : 2012-12-06
Category : Medical
ISBN : 1461533988

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The biology of solid tumor metastasis has been the subject of significant scientific and clinical interest for years and while experimental evidence reveals that metastasis is not solely a random event, very little is known about the biology of metastasis originating from prostate cancer. This is in spite of the fact that the majority of prostate cancer patients die with metastatic lesions to the bone. Progress in understanding this most important aspect of prostate cancer has been hampered by the lack of suitable animal models and an inability to accurately quantify bone metastases and their responses to therapy. Over the past decade, scientists in Japan and the United States have steadily advanced our understanding of the cellular, molecular and immunologic biology of primary and disseminated prostate cancer. It is this body of new information, combined with advances in imaging techniques and prostate cancer tumor markers, that prompted the need for an in-depth assessment of bone metastasis of prostate cancer. Accordingly, on December 12, 1990, a group of basic and clinical investigators from Japan and the United States convened in Gotenba, Japan, to hold the first conference devoted solely to the basic biology and clinical aspects of bone metastases originating from prostate cancer. The cross-fertilization of ideas that was fostered through in-depth discussion of technological advances among various basic and clinical disciplines not only further advanced our understanding of prostate metastases to the bone, but suggested approaches for precise quantitative assessment of these lesions and their treatment.

Author : R. Lor Randall
Publisher : Springer
Page : 356 pages
File Size : 32,90 MB
Release : 2015-12-01
Category : Medical
ISBN : 1461456622

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Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and bio targeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike.

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
Page : 2004 pages
File Size : 24,75 MB
Release : 2017-03-10
Category : Medical
ISBN : 111900084X

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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Thomas N. Byrne
Publisher : Oxford University Press
Page : 429 pages
File Size : 26,94 MB
Release : 2000-01-13
Category : Language Arts & Disciplines
ISBN : 0195129687

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Diseases of the Spine and Spinal Cord reviews the full spectrum of disorders affecting this region including primary spinal tumors and metastases, infection, degenerative diseases, and trauma. Presenting an inter-disciplinary perspective, the book includes up-to-date information on therapy [including neurosurgical], new information on developmental disorders of the spine, and a definitive chapter on trauma, including information on biomechanics. A separate chapter on pain syndromes also is included.

Author : Mahul B. Amin
Publisher : Lippincott Williams & Wilkins
Page : 2443 pages
File Size : 24,80 MB
Release : 2013-11-14
Category : Medical
ISBN : 1469857960

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Knowledge in the field of urologic pathology is growing at an explosive pace. Today’s pathologists, specialists, and residents require a comprehensive and authoritative text that examines the full range of urological diseases and their diagnosis. Written by recognized leaders and educators in the field, the text provides readers with a detailed understanding of all diagnostic aspects of urological disease. Inside this unique resource, readers will explore a broad spectrum of practical information—including etiology, diagnostic criteria, molecular markers, differential diagnosis, ancillary tests, and clinical management. This is sure to be the new definitive text for urological pathology!

Author : Jaime Paulos
Publisher : Springer Nature
Page : 238 pages
File Size : 44,89 MB
Release : 2021-07-15
Category : Medical
ISBN : 1447175018

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This book reviews the latest techniques for diagnostics and treatments specific to bone and soft tissue tumors. It focuses on imaging and classification of the bone and soft tissue tumors and how histology and cytogenetic aspects can be used to identify tumors. Each chapter focuses on a specific type of tumor, providing a concise overview of relevant information on their characteristics along with the latest surgical and medical treatments available. Bone Tumors: Diagnosis and Therapy Today is a concise guide to successfully identifying and treating bone and soft tissue tumors, making it a valuable resource for practicing medical professionals and trainees who encounter these patients in their day-to-day practice.

Author : Simon S. Lo
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 36,22 MB
Release : 2012-08-28
Category : Medical
ISBN : 364225604X

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Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Author : Vassilios Vassiliou
Publisher : Springer Science & Business Media
Page : 479 pages
File Size : 27,31 MB
Release : 2013-11-19
Category : Medical
ISBN : 9400775695

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The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.

Author : Andrew Davies
Publisher : Oxford University Press
Page : 127 pages
File Size : 41,78 MB
Release : 2007-11-15
Category : Medical
ISBN : 0199215731

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Cancer-related bone pain is experienced by patients with primary bone tumours such as myeloma and osteosarcoma, but is more commonly seen in patients with malignant tumours that have metastasised to bone. Bone pain is one of the most common and severe forms of pain associated with breast, prostate and lung cancer, yet little is known about the underlying mechanisms responsible for the pain. Cancer patients identify bone pain as the most disruptive cancer-related event in terms oftheir quality of life and daily functioning, and it is also associated with increased incidence of morbidity, depression, and anxiety.Part of the Oxford Pain Management Library, this volume summarises the latest evidence-based and practical information on the management of cancer-related bone pain. Chapters cover the pathophysiology and clinical features of bone pain, general principles of management and the use of opioids and other agents. It will be an invaluable reference for all health care professionals involved in the management of patients with bone pain from various disciplines including palliative care,anaesthetics, oncology and general practice.