[PDF] Biocatalysis In Organic Synthesis 3 eBook

Author : Animesh Goswami
Publisher : Academic Press
Page : 440 pages
File Size : 31,91 MB
Release : 2015-09-06
Category : Science
ISBN : 012411542X

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Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Author : Nicholas J. Turner
Publisher : Royal Society of Chemistry
Page : 416 pages
File Size : 40,22 MB
Release : 2018-02-08
Category : Science
ISBN : 1782625305

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The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.

Author : Kurt Faber
Publisher : Thieme
Page : 944 pages
File Size : 40,90 MB
Release : 2015-03-11
Category : Science
ISBN : 3131766611

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The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis" present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. "Biocatalysis in Organic Synthesis" offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 3 begins with oxidation. A chapter on enzyme-catalyzed dihydroxylation is followed by reviews of alkane oxidation. Oxidations of alcohols, carbonyl compounds, and heteroatoms are covered, as are halogenations. The use of biocatalysts in total synthesis, cascade reactions, and large-scale industrial applications is considered. Finally, emerging trends are discussed.

Author : Karlheinz Drauz
Publisher : John Wiley & Sons
Page : 2143 pages
File Size : 16,24 MB
Release : 2012-03-26
Category : Science
ISBN : 3527325476

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This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis. Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field. All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach. A must for all chemists and biotechnologists.

Author : Kurt Faber
Publisher :
Page : 0 pages
File Size : 45,51 MB
Release : 2015
Category : Biocatalysis
ISBN : 9783131746719

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The three Science of Synthesis volumes on Biocatalysis in Organic Synthesis present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. Biocatalysis in Organic Synthesis offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 3 begins with oxidation. A chapter on enzyme-catalyzed dihydroxylation is followed by reviews of alkane oxidation. Oxidations of alcohols, carbonyl compounds, and heteroatoms are covered, as are halogenations. The use of biocatalysts in total synthesis, cascade reactions, and large-scale industrial applications is considered. Finally, emerging trends are discussed.

Author : Kurt Faber
Publisher : Thieme/Houben-Weyl Series
Page : 712 pages
File Size : 45,39 MB
Release : 2015
Category : Science
ISBN : 9783131746610

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The three Science of Synthesis volumes on Biocatalysis in Organic Synthesis present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. Biocatalysis in Organic Synthesis offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 3 begins with oxidation. A chapter on enzyme-catalyzed dihydroxylation is followed by reviews of alkane oxidation. Oxidations of alcohols, carbonyl compounds, and heteroatoms are covered, as are halogenations. The use of biocatalysts in total synthesis, cascade reactions, and large-scale industrial applications is considered. Finally, emerging trends are discussed.

Author : Kurt Faber
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 20,5 MB
Release : 2012-12-06
Category : Science
ISBN : 3642974236

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The use of natural catalysts - enzymes - for the transformation of non-natural is not at all new: they have been used for more man-made organic compounds than one hundred years, employed either as whole cells, cell organelles or isolated enzymes [1]. Certainly, the object of most of the early research was totally different from that of the present day. Thus the elucidation of biochemical pathways and enzyme mechanisms was in the foreground of the reasearch some decades ago. It was mainly during the 1980s that the enormous potential of applying natural catalysts to transform non-natural organic compounds was recognized. What started as a trend in the late 1970s could almost be called a fashion in synthetic organic chemistry in the 1990s. Although the early euphoria during the 'gold rush' in this field seems to have eased somewhat, there is still no limit to be seen for the future development of such methods. As a result of this extensive, recent research, there have been an estimated 5000 papers published on the subject [2]. To collate these data as a kind of 'super-review' would clearly be an impossible task and, furthermore, such a hypothetical book would be unpalatable for the non-expert.

Author : Kurt Faber
Publisher :
Page : 0 pages
File Size : 34,91 MB
Release : 2015
Category : Biocatalysis
ISBN : 9783132028715

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The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis" present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. "Biocatalysis in Organic Synthesis" offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis.

Author : John Whittall
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 45,98 MB
Release : 2016-02-16
Category : Technology & Engineering
ISBN : 1118696298

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Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities. Practical Methods for Biocatalysis and Biotransformations 3 will be a companion book to Practical Methods for Biocatalysis and Biotransformations (2009) and Practical Methods for Biocatalysis and Biotransformations 2 (2012). Following the successful format of the two volumes, it will be a “how-to” guide focusing on commercially available enzymes and strains of microorganisms that are readily obtained from culture collections. The source of starting materials and reagents, hints, tips and safety advice (where appropriate) will be given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology will be given and relevant references to the primary literature will be cited. Contents include: Biotransformation Process Technology Industrial Biooxidation Hydrolase catalysed hydrolysis/synthesis Reduction Oxidation Halogenation Transferase catalysed glycosylation, methylation, etc C-C bond formation Tandem Biocatalytic Reactions Practical Methods for Biocatalysis and Biotransformations, Volume 3 is an essential collection of validated biocatalytic methods which will find a place on the bookshelves of synthetic organic chemists, pharmaceutical chemists, and process R&D chemists in industry and academia.