[PDF] Atopic Dermatitis And Pruritus eBook

Author : Kiran Godse
Publisher : Jaypee Brothers Medical Publishers
Page : 152 pages
File Size : 18,3 MB
Release : 2021-02-28
Category : Medical
ISBN : 9351522385

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Atopic dermatitis, or eczema, is a condition that makes the skin red and itchy. It is common in children but can occur at any age. Atopic dermatitis is long lasting (chronic) and tends to flare periodically. It may be accompanied by asthma or hay fever. No cure has been found for atopic dermatitis, but treatments and self-care measures such as avoiding harsh soaps, moisturising, and applying medicated creams or ointments, can relieve itching and prevent new outbreaks. Pruritus, or itchy skin, is an uncomfortable, irritating sensation that makes a person want to scratch. It is often caused by dry skin and is more common in older adults, as skin tends to become drier with age. Depending on the cause of the itchiness, the skin may appear normal, red, rough or bumpy. Repeated scratching can cause raised thick areas of skin that might bleed or become infected. Many people find relief with self-care measures such as moisturising daily, using gentle cleansers and bathing with lukewarm water. Long-term relief requires identifying and treating the cause of itchy skin. Common treatments are medicated creams, moist dressings and oral anti-itch medicines. This book presents 30 clinical cases of patients with atopic dermatitis or pruritus. Each case is explained in a step-by-step manner, detailing history and symptoms, investigation techniques, diagnosis, and management. Many cases cover comorbid conditions associated with these skin disorders. Authored by recognised experts from worldwide Atopic Dermatitis Centres of Reference and Excellence (ADCARE), the practical text is further enhanced by photographs and figures. Key points Practical guide to diagnosis and management of atopic dermatitis and pruritus 30 clinical cases cover different skin conditions, many with comorbid conditions Authored by experts from Atopic Dermatitis Centres of Reference and Excellence Features photographs and figures to assist learning

Author : E. Carstens
Publisher : CRC Press
Page : 482 pages
File Size : 22,14 MB
Release : 2014-02-25
Category : Science
ISBN : 1466505435

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Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Author : Robin Thurmond
Publisher : Springer Science & Business Media
Page : 153 pages
File Size : 13,95 MB
Release : 2011-06-29
Category : Medical
ISBN : 1441980563

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The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

Author : Thomas Ruzicka
Publisher : Springer Science & Business Media
Page : 491 pages
File Size : 18,78 MB
Release : 2013-03-09
Category : Medical
ISBN : 3662026716

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State-of-the-art review on atopic eczema, one of the most common skin diseases today. This multi-authored handbook covers all aspects relevant for physicians from various disciplines.

Author : Alan Cowan
Publisher : Springer
Page : 384 pages
File Size : 33,74 MB
Release : 2015-04-10
Category : Medical
ISBN : 3662446057

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Basic research on the pharmacology of itch has exploded in the wake of two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and clinical communities because of its complexity and its negative effects on the quality of life of the distressed patients. Like pain, not all itches are the same. Unlike pain, there are no standard drugs equivalent to aspirin and morphine. Epidemiological studies emphasize the high incidence and economic costs of itch (pruritus). It is the most prevalent symptom of a wide variety of allergic and inflammatory skin conditions (e.g., psoriasis, atopic dermatitis), is associated with several systemic diseases (e.g., chronic kidney and liver disease), and occurs in patients undergoing hemodialysis, spinal administration of opioids, and in those suffering from AIDS. The reader will learn about the multiple pathways for itch and their interactions with pain. The relationship between these closely related, yet distinct sensory phenomena, will be emphasized. Both itch and pain use several common molecules to send signals to the brain. Thus, drugs that have been, and are being, developed as analgesics may also attenuate intractable itch. This has been an exciting and very necessary turn of events since traditional H-1 receptor antagonists are ineffective in blocking the pruritus associated with kidney failure and cholestasis. The clinical chapters will provide insights into contemporary treatment regimens for pruritus in different human scenarios.

Author : Ana M. Gimenez-Arnau
Publisher : CRC Press
Page : 304 pages
File Size : 38,28 MB
Release : 2014-11-05
Category : Medical
ISBN : 1466598050

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Contact urticaria syndrome was first defined in 1975 and since then scientific interest has steadily increased. New cases are continuously being reported furnishing information on novel clinical features. A large number of compounds could be responsible for triggering the syndrome including fragrances, cosmetics, latex, preservatives, flavorings, a

Author : Laurent Misery
Publisher : Springer Science & Business Media
Page : 324 pages
File Size : 15,24 MB
Release : 2010-01-22
Category : Medical
ISBN : 1848823223

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Numerous treatments have been proposed. But the treatment of itch remains difficult and it depends on its etiology. The understanding of the pathophysiogeny of itch is necessary. Fortunately, many very interesting results of research have been reported in the recent years. 'Pruritis' will explain the pathophysiogeny of itch, describe all causes, and give guidelines for management and treatment.

Author : Gil Yosipovitch
Publisher : CRC Press
Page : 428 pages
File Size : 40,37 MB
Release : 2004-01-06
Category : Medical
ISBN : 0824759745

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Offering details on the pharmacology of itch, techniques of itch evaluation, and neurogenic itch, this reference presents new concepts in the neurophysiology and central mechanisms of itch, animal models of itch, and processing of histamine itch in the human cerebral cortex. The text clarifies itch in systemic and skin disease, exploring renal itch