[PDF] Amino Acid Derived Transition Metal Complexes Structural And Catalytic Studies eBook

Author :
Publisher :
Page : 512 pages
File Size : 44,57 MB
Release : 2009
Category :
ISBN :

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A group of ligands were designed based on a minimalist reduction of the structure of metalloproteins. It was thought that a modular design with facile synthesis could lead to a new family of privileged ligands. Towards this goal a series of tri-, tetra, and penta-dentate ligands were synthesized. The ligands had a common chiral core based on inexpensive amino acid starting materials. A modular diamine backbone was adjusted to control the size, bite angle and electronic nature of the binding pocket. The ligands were capped with Schiff base imines to provide an initial binding point for the metal and to create steric bulk at one face of the complex. The tetra-dentate ligands were shown to efficiently bind zinc(II), copper((II), nickel(II), and palladium(II). In the case of the penta-dentate ligands the series was extended to cobalt(II), manganese(II) and iron(II). The tri-dentate ligands did not form isolated metal complexes. The structures of these complexes were confirmed by NMR, ESR and X-ray crystallography. The chiral copper complexes were applied to a model asymmetric acylation reaction. The results were disappointing as the reactions showed no stereoselectivity.

Author : Jon Paul Janet
Publisher : American Chemical Society
Page : 189 pages
File Size : 35,81 MB
Release : 2020-05-28
Category : Science
ISBN : 0841299005

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Recent advances in machine learning or artificial intelligence for vision and natural language processing that have enabled the development of new technologies such as personal assistants or self-driving cars have brought machine learning and artificial intelligence to the forefront of popular culture. The accumulation of these algorithmic advances along with the increasing availability of large data sets and readily available high performance computing has played an important role in bringing machine learning applications to such a wide range of disciplines. Given the emphasis in the chemical sciences on the relationship between structure and function, whether in biochemistry or in materials chemistry, adoption of machine learning by chemistsderivations where they are important

Author : Ewa Broclawik
Publisher : Springer
Page : 532 pages
File Size : 35,45 MB
Release : 2019-03-16
Category : Science
ISBN : 3030117146

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This book focuses on the electronic properties of transition metals in coordination environments. These properties are responsible for the unique and intricate activity of transition metal sites in bio- and inorganic catalysis, but also pose challenges for both theoretical and experimental studies. Written by an international group of recognized experts, the book reviews recent advances in computational modeling and discusses their interplay using experiments. It covers a broad range of topics, including advanced computational methods for transition metal systems; spectroscopic, electrochemical and catalytic properties of transition metals in coordination environments; metalloenzymes and biomimetic compounds; and spin-related phenomena. As such, the book offers an invaluable resource for all researchers and postgraduate students interested in both fundamental and application-oriented research in the field of transition metal systems.

Author : John L Burmeister
Publisher : World Scientific
Page : 654 pages
File Size : 37,20 MB
Release : 2003-10-14
Category : Science
ISBN : 9814488003

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This invaluable book distils the research accomplishments of Professor Fred Basolo during the five decades when he served as a world leader in the modern renaissance of inorganic chemistry. Its primary focus is on the very important area of chemistry known as coordination chemistry.Most of the elements in the periodic table are metals, and most of the chemistry of metals involves coordination chemistry. This is the case in the currently significant areas of research, including organometallic homogenous catalysis, biological reactions of metalloproteins, and even the solid state extended structures of new materials. In these systems, the metals are of primary importance because they are the sites of ligand substitution or redox reactions. In the solid materials, the coordination number of the metal and its stereochemistry are of major importance.Some fifty years of research on transition metal complexes carried out in the laboratory of Professor Basolo at Northwestern University is recorded here as selected scientific publications. The book is divided into three different major research areas, each dealing with some aspect of coordination chemistry. In each case, introductory remarks are presented which indicate what prompted the research projects and what the major accomplishments were. Although the research was of the academic, curiosity-driven type, some aspects have proven to be useful to others involved in projects that were much more applied in nature.

Author : Marine Desage-El Murr
Publisher : John Wiley & Sons
Page : 373 pages
File Size : 31,78 MB
Release : 2024-01-31
Category : Science
ISBN : 352783088X

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Redox-Active Ligands Authoritative resource showcasing a new family of ligands that can lead to better catalysts and promising applications in organic synthesis Redox-Active Ligands gives a comprehensive overview of the unique features of redox-active ligands, describing their structure and synthesis, the characterization of their coordination complexes, and important applications in homogeneous catalysis. The work reflects the diversity of the subject by including ongoing research spanning coordination chemistry, organometallic chemistry, bioinspired catalysis, proton and electron transfer, and the ability of such ligands to interact with early and late transition metals, lanthanides, and actinides. The book is divided into three parts, devoted to introduction and concepts, applications, and case studies. After the introduction on key concepts related to the field, and the different types of ligands and complexes in which ligand-centered redox activity is commonly observed, mechanistic and computational studies are described. The second part focuses on catalytic applications of redox-active complexes, including examples from radical transformations, coordination chemistry and organic synthesis. Finally, case studies of redox-active guanidine ligands, and of lanthanides and actinides are presented. Other specific sample topics covered include: An overview of the electronic features of redox-active ligands, covering their historical perspective and biological background The versatility and mode of action of redox-active ligands, which sets them apart from more classic and tunable ligands such as phosphines or N-heterocyclic carbenes Preparation and catalytic applications of complexes of stable N-aryl radicals Metal complexes with redox-active ligands in H+/e- transfer transformations By providing up-to-date information on important concepts and applications, Redox-Active Ligands is an essential reading for researchers working in organometallic and coordination chemistry, catalysis, organic synthesis, and (bio)inorganic chemistry, as well as newcomers to the field.

Author : Robina Aman
Publisher : LAP Lambert Academic Publishing
Page : 184 pages
File Size : 47,72 MB
Release : 2013
Category :
ISBN : 9783659430596

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The tetravalent metal complexes of amino acid derivative containing the M-O and M-N linkage display significant and versatile biological activity. The studies are likely to be a meaningful addition in the area of work now being pursued on the reactivity of metal alkoxides. The work described in this book broadly concerns with the synthesis, characterization of several tetravalent metal complexes of amino acid substituted ligands. The structures of the synthesized compounds were confirmed by elemental analysis, IR and 1H-NMR spectra. The present research work is divided into four chapters and all four chapters end with the references.The book is contained much useful spectral data, analytical detail and solubility behavior in the form of tables. This book not only fulfils the requirements of the new synthesis but also helpful for the researchers. In future we can do biological activities such as anti-tumor, anti-ulcer, anti-carcinogenesis, anti-inflammatory, herbicidal, insecticidal and further antimicrobial activities of these silicon, tin- and organotin(IV) complexes. In case of Titanium complexes we can do the, antimicrobial studies and catalytic property.

Author : Yoshiaki Nishibayashi
Publisher : John Wiley & Sons
Page : 510 pages
File Size : 41,40 MB
Release : 2019-01-25
Category : Science
ISBN : 3527344276

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A comprehensive book that explores nitrogen fixation by using transition metal-dinitrogen complexes Nitrogen fixation is one of the most prominent fields of research in chemistry. This book puts the focus on the development of catalytic ammonia formation from nitrogen gas under ambient reaction conditions that has been recently repowered by some research groups. With contributions from noted experts in the field, Transition Metal-Dinitrogen Complexes offers an important guide and comprehensive resource to the most recent research and developments on the topic of nitrogen fixation by using transition metal-dinitrogen. The book is filled with the information needed to understand the synthesis of transition metal-dinitrogen complexes and their reactivity. This important book: -Offers a resource for understanding nitrogen fixation chemistry that is essential for explosives, pharmaceuticals, dyes, and all forms of life -Includes the information needed for anyone interested in the field of nitrogen fixation by using transition metal-dinitrogen complexes -Contains state-of-the-art research on synthesis of transition metal-dinitrogen complexes and their reactivity in nitrogen fixation -Incorporates contributions from well-known specialists and experts with an editor who is an innovator in the field of dinitrogen chemistry Written for chemists and scientists with an interest in nitrogen fixation, Transition Metal-Dinitrogen Complexes is a must-have resource to the burgeoning field of nitrogen fixation by using transition metal-dinitrogen complexes.

Author : Eva Neumann
Publisher : Cuvillier Verlag
Page : 244 pages
File Size : 20,66 MB
Release : 2006-02-15
Category : Science
ISBN : 3736918011

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The term ligand [latin, ligare = bind] has its origin in coordination chemistry. It denotes a molecule that is able to bind to a metal center in most cases via one or several free electron pairs.[1] Ligands can be described by the number of electron-pair donor atoms as monodentate, bidentate, tridentate etc. ligands. The latter are also called chelating ligands [greek, chele = (crab’s) claw]. A typical classification of ligands is according to their electronic properties. They serve either as a σ-donating, σ-donating/π-accepting, or σ,π-donating/π-accepting ligands.[2] A more practical, often encountered approach is the classification of ligands according to their donor atoms, especially when larger molecules and molecules containing heteroatoms are regarded (compare 1.2). Coordination chemistry was already established in the 19th century. In 1893 Alfred Werner suggested an octahedral arrangement of ligands coordinated to a central metal ion for many compounds. This explained, for example, the appearance and reactivity of four different cobalt(III) complexes (Figure 1.1), when CoCl2 is dissolved in aqueous ammonia and then oxidized by air to the +3 oxidation state. The formulas of these complexes can be written as depicted in Figure 1.1. Werner’s work was rewarded with the Nobel prize in 1913.[3]

Author : Françoise Colobert
Publisher : John Wiley & Sons
Page : 294 pages
File Size : 38,87 MB
Release : 2019-11-11
Category : Science
ISBN : 3527343407

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Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.

Author : Andrew B. Hughes
Publisher : John Wiley & Sons
Page : 33 pages
File Size : 35,45 MB
Release : 2011-01-25
Category : Science
ISBN : 3527321020

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This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides This third volume in the series presents an in depth account of recent developments in the (bio-)synthesis of amino acids and peptides. Divided into two parts, the first section deals with amino acids as building blocks, including the generation of alpha-amino acids, beta-lactams, and heterocycles. The second section is devoted to the synthesis of peptides, with the focus on solid phase synthesis. However, solution phase peptide synthesis is covered as well, as are topics such as coupling reagents, chemical ligation, peptide purification and automation. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.